Uterine anomalies play an understated role in the common perception of endometriosis. While they often have been associated with infertility cases, they also can have an effect in the development of endometriosis. In fact, in our own clinical setting, we have found that 38% of our patients who had a mild form of uterine structure abnormality, specifically arcuate uterus upon hysteroscopic evaluation, tested positive for endometriosis. This is significant to note as less than 5% of the females on average have been found to have arcuate uterus upon hysteroscopic evaluation. This means that patients with endometriosis have a statistically higher chance of having an arcuate uterus in comparison to the general population. For these reasons, we think it is highly important to shed light on uterine malformations and the impact they can have on endometriosis patients.
What is a uterine anomaly?
Uterine anomalies, also known as uterine malformations, are female genital malformations that often result from abnormal development. They can result in physical mishappening of the uterus or more subtle abnormalities within the uterine cavity. Some of these differences have been found to be associated with such conditions as pelvic pain, infertility, and even endometriosis.
Different forms of uterine anomalies?
Malformations of the uterus can take various different forms, ranging from major uterine cavity physical changes to more subtle abnormalities. In a 2011 observational study conducted by Chan et al [ 1 ], 94 patients with abnormal uteri (5.5% of the total population of patients), were studied in order to determine some of the most common forms of anomalies. The findings included the following:
Arcuate uterus: This term has been classically difficult to define but represents a mild form of a septal uterus. The myometrium of the fundus (the top portion of the uterus, opposite of the cervix) dips inward into the uterine cavity, possibly causing a small septation. This division is part of the reason why arcuate uterus is so challenging to define, as it can be difficult to discern this from the more pronounced septate uterus. In fact, in Europe, the term “arcuate uterus” is not even made because all of these uteri either fall under the category of a normal or septate uterus. However, when defined separately from the septate uterus by having a midline prominence of 1.5cm or less, the arcuate uterus was found to make up 70% of uterine abnormalities. While it does not have any obstetrical implications—meaning it has not been found to have an association with infertility or miscarriages—it has shown some correlations with other gynecological diseases, such as endometriosis. For this reason, it can be highly beneficial to separate arcuate uterus as a subcategory of a septate uterus.
Septate uterus: A malformation in which the uterine cavity is divided by a septum protruding from the fundus, while the normal outer shape remains intact. Medical theories debate the distinction between arcuate and septate uterus. Recent studies have shown though, that septate uterus is less common in patients without a history of infertility in comparison to the more subtle form that is the arcuate uterus [ 2 ]. In other words, a septate uterus is a common anomaly in women with a history of miscarriages and infertility, which was found in over 15% of women in the study. There are also rare instances where this septum completely divides the uterine cavity and cervix into two halves, termed uterine didelphis (double uterus).
Bicornuate uterus: Bicornuate uterus is a uterine duplication anomaly caused by a partial failure of fusion of the Müllerian ducts (connection between the uterine cavity and fallopian tubes). It accounts for approximately 25% of congenital uterine anomalies. It is characterized by an outer fundal cleft that is greater than 1cm and a wide intercornual (tube) distance that can be appreciated via hysteroscopy and laparoscopy. A bicornuate uterus cannot be treated with simple resection and surgical intervention is not necessarily indicated. Nevertheless, it is associated with a risk of recurrent pregnancy loss, cervical incompetence, and possible cerclage placement. The hysteroscope can be used to explore the two uterine horns and appreciate the depth and angle of the two horns. Surgical correction can be performed in cases of reproductive failure but is best handled by a reproductive specialist.
Unicornuate uterus: This form of uterine anomaly is also known as a “one-sided uterus.” The uterus is blocked from one side, closing of one of the two Müllerian ducts. This abnormality appears as a “banana shape” in imaging tests and has been shown to cause significant effects in infertility cases, which includes a greater risk of miscarriage, preterm delivery, and in some cases, ectopic pregnancy. [ 3 ]
Müllerian agenesis: This uterine anomaly is known as Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome and defines the underdevelopment or complete absence of the uterus. While rare, it has tremendous impacts on the reproductive system as patients are usually infertile and lack a menstrual period due to the absence of the uterus.
What can uterine anomalies cause?
The effects of uterine anomalies can vary from patient to patient. One common complication that structure anomaly can lead to is painful peristalsis (dysperistalsis) and abnormal outflow of menstrual debris, thereby potentially increasing reflux of retrograde flow that can participate in endometriosis development. While some normal menstrual flow is expelled out of the uterus, retrograde reflux blood and debris can move into the fallopian tubes and pool into the pelvic cavity and peritoneum, leading to endometriosis development.
How can uterine anomalies be observed?
Hysteroscopy: Hysteroscopic evaluation is very important when a patient receives laparoscopic evaluation and surgery. It uses a hysteroscope (camera) to visualize the uterine cavity by inserting the device vaginally. Using this imaging technique, a trained surgeon is able to identify any uterine anomalies, including the arcuate uterus, septal uterus, etc. This procedure is a crucial part of any thorough gynecological surgery performed in the operating room in order to assess whether or not a septum appears within the uterine cavity, and if so the extent of such. Thus any hysteroscopy should be accompanied by laparoscopic surgery for endometriosis.
MRI: Magnetic resonance imaging (MRI) is a preoperative medical imaging technique used in radiology to form pictures of the inner anatomy and organs. Using magnetic fields and radio waves, an MRI is able to make out abnormal intrauterine structures, which bodes highly useful in presumptively diagnosing a believed form of uterine anomaly. 
Endometriosis & Uterine Anomalies
Both obstructive and nonobstructive uterine anomalies have been associated with endometriosis. One common explanation for this relationship is due to the abnormal menstrual flow associated with these uterine anomalies. Reverse peristalsis occurs so sperm can swim upstream and travel into the fallopian tubes and combine with an egg. This ability is believed to be driven by coordinated contractions of uterine muscular fibers, which could possibly have differential activation. In cases of uterine abnormalities, retrograde menstrual debris can take advantage of this pathway and move backward into the fallopian tubes, ovaries, peritoneum, and pelvic cavity. All of these areas are common sites for the endometrial tissue, stem cells, and inflammatory enzymes contained within this reflux debris to latch onto and eventually develop into endometriosis lesions. Therefore, uterine anomalies can pose as another suspected cause of endometriosis, secondary to retrograde menstruation.
Endometriosis & arcuate uterus
While arcuate uterus is often considered a normal anatomical variation with questionable reproductive repercussions, it must be recognized as a pathological finding in endometriosis patients. In fact, our studies have shown abnormal arcuate architecture and its subtle forms are associated with increased prevalence of both peritoneal and advanced endometriosis. As a result, what arcuate uterus means for an obstetric patient (infertility case) is different than that for the endometriosis patient. Continued testing and identification of arcuate uterus is thus important for endometriosis patients, as potential resection of midline prominence may be a significant step for treatment of endometriosis patients.
How do we assess uterine abnormalities?
At the Seckin Endometriosis Center, we feel that is crucial to assess the uterine structure and function of each patient who comes in for surgery. We conduct a hysteroscopy on all of our patients who come in for surgery in order to assess any uterine abnormalities, which we have found could be associated with endometriosis. We also advise our patients to receive an MRI pre-surgery to provide us with a presumptive understanding of the uterus structure.
How do we define and assess arcuate uterus?
An arcuate uterus is the mildest form of a septal uterus. While it is considered to be a normal variation from an obstetrical standpoint, we have found it to be a much more common anomaly in our endometriosis patients. For these reasons, it is highly important to make the distinction between arcuate and septal uteruses. The sub-distinction between the two abnormalities is seen in the differing length of midline protuberance, which we cut off at 1.5cm. However, we believe that these anomalies should also be defined in a more continuous definition, in terms of midline defect or degree of “arcuateness” (ranging from mild to severe).
We always look to assess these anomalies and this distinction in our surgeries through the use of hysteroscopy. During this procedure, we look to surgically identify arcuate uterus through four key criteria points: midline prominence, vertical stria, bilateral cornual funneling, and dilation of tubal ostia. The first criteria point is seeing whether or not a septum exists by evaluating midline prominence. We then look to identify any vertical stria, which are stretch marks that can exist when the uterus is misshapen, such as when the fundus concaves inward. The next key component to evaluate are the Müllerian ducts, a common site for abnormalities to take place in arcuate uteruses due to abnormal development during embryogenesis (embryo development). We look to examine if there is proper cornual funneling of the uterus into the fallopian tubes on both sides. We also look to make sure there is proper dilation of the tubal ostia, which is the proper widening of the tubes themselves. In cases of an arcuate uterus, sometimes the funneling of these tubes can come earlier and narrower due to the minor septum formed within the uterine cavity. These are important factors to take into account when assessing the uterus for any structural abnormalities during a hysteroscopy.
Our data on uterine abnormalities
Based on the many hysteroscopies we have performed, our clinical research data has shown that our endometriosis patients are commonly prone to having uterine abnormalities, specifically arcuate uterus. Of the 260 hysteroscopies we performed from 2015-2016, 100 (38%) showed arcuate uterus and minor variations, while the other 160 (62%) patients had a normal uterine cavity. This is a notable similarity of what was found in a study by LaMonica et. All, which showed 37% of endometriosis patients to have arcuate uterus upon laparoscopic and hysteroscopic procedures. While this is, in fact, not a majority, it is significant to note as an arcuate uterus is reported to be in less than 5% of females according to recent studies. Of these 100 patients that had an arcuate uterus, nearly 60% of their excision specimens came back positive for endometriosis on average. The remaining specimens showed inflammation and fibrosis.
On top of this, 39 cases of endometrioma came back as positive out of the 100 patients (39%) with an arcuate uterus, whereas only 38 out of 160 normal (24%) uterine cases of endometrioma were positive.This is important to note as this means that uterine anomalies brought a 1.76 fold more incidence of ovarian endometrioma than those with a normal uterus. These endometriomas, in turn, can lead to further development of endometriosis to the point of stage 3 or 4 deep infiltrating endometriosis.
Thus it was found that patients with an arcuate uterine cavity have a statistically significant higher number of positive endometriosis and endometrioma specimens per case than the average patient with a normal uterus. This was shown to be true in cases of endometrioma, and can therefore very well be assumed to have an impact on more severe cases of deep infiltrating uterus. All of this is crucial to note as it shows that what arcuate uterus means for the obstetric patient appears to be different than for cases of endometriosis. Therefore, identification of arcuate uterus through hysteroscopy is important for endometriosis patients. It also suggests that potential resection of midline prominence may be a significant step for surgical treatment of endometriosis patients.
At the Seckin Endometriosis Center, we take great care in understanding our patients, both from a surgical and personal perspective. Endometriosis patients are some of the strongest women around, and they deserve the strongest care. We take great pride in assuring that no stone goes unturned in your case. Assessing uterine abnormalities and their possible effects on your case is no exception.
Our office is located on 872 Fifth Avenue New York, NY 10065. You may call us at (646) 960-3080 or have your case reviewed by clicking here.
Chan Y, Jayaprakasan K, Zamora J, Thornton J, Raine-Fenning N, Coomarasamy A. “The Prevalence of Congenital Uterine Anomalies in Unselected and High-Risk Populations: A Systematic Review.” Hum Reprod Update. 2011;17(6):761-771
Woelfer B, Salim R, Banerjee S, Elson J, Regan L, Jurkovic D. “Reproductive Outcomes in Women with Congenital Uterine Anomalies Detected by Three-Dimensional Ultrasound Screening.” Obstet Gynecol. 2001;98(6): 1099-1103.
Leyendecker G, Kunz G, Wildt L, Beil D, Deininger H. “Uterine Hyperperistalsis and Dysperistalsis as Dysfunctions of the Mechanism of Rapid Sperm Transport in Women with Endometriosis and Infertility.” Human Reprod. 1996;11(7):1542-1551.
LaMonica R, Pinto J, Luciano D, Lyapis A, Luciano A. “Incidence of Septate Uterus in Reproductive-Aged Women with and Without Endometriosis.” J Minim Invasive Gynecol. 2016;23(4):610-613.
I’ve seen many obgyns over the years explaining my monthly symptoms during my period...but eventually it became a daily struggle with these pain. It feels like a poke here and there near my right pelvic region. I was given birth control pills for the past ten years but honestly, it didn’t help at all. I was in bed whenever I…
Dr.Seckin is so much more than a surgeon. His passion for helping endometriosis sufferers and determination to improve the quality of life in all of his patients is undeniable. I remember when my gynecologist first told me I needed a laparoscopy. Her exact words were "I can do the surgery, but if you were MY daughter- I'd send you to…
I was there for hysterectomy but then I found out that I also had endometriosis.My both surgeries went excellent and I feel great!.I am so thankful to Dr.Seckin and all his team for making my journey smooth!
I am a physician who suffered from deep infiltrative endometriosis. I needed laparoscopic surgery, so I went to see my former gynaecologist and he performed the procedure (a surgery which he supposedly does hundreds of times a year) last November. I had severe pain again when I had my period in January and was advised to go on taking a…
After years of excessively painful periods, a serious loss of quality of life, and a series of uninformed and uninterested doctors, Dr. Seckin and Dr. Goldstein turned my life around. I was told I woke up from my surgery almost a year ago with a smile on my face, and I haven't stopped since. Before I heard of Dr. Seckin,…
Dr Seckin and his team gave me back my life! Tomorrow will be 1 month since my surgery and I feel great. Dr. Seckin, Dr Liu, and Dr Goldstein are not only beyond words talented and amazing Doctors, but they are also genuinely wonderful and caring people. I cannot say enough great things about Holly, Asiye and Kim as well.…
Dr. Seckin and his staff spared me from years and years of heavy periods and unbearable endometriosis pain. After having surgery with him (my first) I can now function like a regular human. No more eating NSAIDs like candy and calling out sick from work. Thank you, Dr. Seckin!