'Top Chef''s Padma Lakshmi Gets Personal for a Cause


"After 35, chances for a natural pregnancy are going down. If you have endometriosis, that process is significantly affected," said Dr. Tamer Seckin, [Padma] Lakshmi's doctor and co-founder of the Endometriosis Foundation of America.

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Padma Lakshmi, author, model and co-host of Bravo's series "Top Chef," opened up to students and scientists at the Massachusetts Institute of Technology on Friday, where she traveled to raise awareness of endometriosis, a disease of the uterus that affects millions of women.

Lakshmi said endometriosis has interfered with her work for decades and threatened her ability to have children.

Now triumphantly pregnant after receiving treatment, Lakshmi was at the MIT Center for Gynepathology Research shortly after it's opening to tell young women not to ignore the pain of endometriosis.

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The center is run by MIT professor Linda Griffith, an expert in tissue engineering and winner of a prestigious MacArthur "genius'' grant.
"A lot of women are delaying their motherhood from their 20s to their 30s, or even their 40s," said Lakshmi. "Often you find out that you can't have children until it's too late because you never got it treated. And that is a real tragedy."

Endometriosis occurs when the tissue that makes up the lining of the uterus begins to grow outside of the womb for unknown reasons. These lesions of uterine lining can spread to other organs in the abdomen and respond to a woman's hormone cycles -- causing much pain, cramping, scar tissue, and infertility.

Lakshmiwas diagnosed with endometriosis in her 30s, after her acupuncturist told her that he was concerned about her ovaries. "How he knew, I had no idea," she said.

But Lakshmi suspected all along that something was wrong, she just never had the support from her doctors to figure out why she was in so much pain.

"I always wondered why it was that I suffered the worst out of any girl in my class from cramps," said Lakshmi, who added that her own mother suffered from severe period symptoms and tried to prepare her to deal with the pain.

"When I went to a women gynecologist, ironically, she said 'oh it can't be that we all have our periods dear'," said Lakshmi.

Padma Lakshmi Suffered for Years in Pain

As an adult, Lakshmi said her symptoms were so unbearable at times that she would have to arrange her life around her cycles.

She told her assistant to mark the 3 or 4 days each month on the calendar and make no commitments she could not break if the pain got too unbearable.

"Pain is a very solitary, isolating thing. I thought perhaps I was just being a ninny. That's how you feel, you feel thin-skinned, and of course your hormones are out of whack," she said. Because of the isolation, and the initial response from her doctor, Lakshmi continued to suffer through decades in pain.

Eventually, Lakshmi got a proper diagnoses and treatments involving surgery. And now she is pregnant.

"After 35, chances for a natural pregnancy are going down. If you have endometriosis, that process is significantly affected," said Dr. Tamer Seckin, Lakshmi's doctor and co-founder of the Endometriosis Foundation of America.

Seckin explained the scar tissue that forms after endometriosis can twist and pull a woman's reproductive organs out of alignment making it difficult for the egg to reach the fallopian tube. Scar tissue might completely block the tube, or even cover the ovary. Moreover, the uterine lining tissue gives off chemicals that interfere with the sperm reaching the egg.

Add all of that to the natural loss of fertility, and as Lakshmi pointed out, women with endometriosis are at a higher risk of infertility.

"About 30 percent of infertility patients, have it," said Dr. Steven Ory past president of the American Society for Reproductive Medicine and professor at Florida International University in Miami.

Signs of a Hidden Disease

For some women, infertility is the first sign that they have endometriosis, but many experience pain in "painful intercourse, painful periods, or pain in the second half of the menstrual cycle," Ory said.

Even if women go in for an annual exam, endometriosis might be missed. Ory explained doctors frequently use ultrasound and sometimes laparoscopy to diagnose women, which involves inserting a small camera into the abdominal cavity to see lesions of endometriosis.

Hope for More Understanding, Awareness of Endometriosis

Treatments and awareness are slowly improving, but Ory said doctors still don't know why endometriosis forms. One hypothesis is that the problem occurs in fetal development, but the abnormal growth only shows up in puberty when hormones start developing in the uterine lining.

Griffith said others theorize about the fact that a little bit of menstrual flow "refluxes," or backs up, into the fallopian tubes and abdominal cavity each month while a woman is menstruating. An investigator in her lab is studying whether an outside factor such as radiation exposure, somehow makes this lingering uterine lining to grow again in the abdominal cavity.

Mysterious as it is, endometriosis is also very common. An estimated 2 to 10 percent of women in their reproductive years have endometriosis, which could mean 5.5 million women in the U.S. are affected, according to the National Institute of Child Health and Human Development.

Griffith said the goal of the new Center for Gynepathology Research is to discover how endometriosis lesions form, develop treatments and in the process develop new engineering tools that would help a host of other diseases.

Griffith, who also suffers from endometriosis, guesses her center is the first ever to be devoted to endometriosis and gynepathologic research.

"We're not studying gynecology, we're studying things that go wrong with everything below the waist," said Griffith.

Griffith is using her experience in tissue engineering to develop uterine lining using living tissue samples that behave in the lab the same way the lining behaves in a uterus. Once Griffith collects an endometriosis sample from a volunteer and creates a living tissue sample through tissue engineering, she can safely experiment with the uterine lining and never have to experiment on women.

Celebrity Status Helping Science

"We're thrilled that Padma could come," said Griffith. "It is so common that women don't even think about how much they are affected."

Lakshmi agreed. She said she didn't understand what a burden her endometriosis had become until she started receiving treatment.

"For the last 20 years that I could have had so much more done, been so much more productive… never mind the dollars of income lost, just the time and moments with the people I care about," said Lakshmi.

"It's only now that my pain has diminished -- by I'd say 80 percent -- that I can see in hindsight how much pain I was in," she said.

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Scientist takes aim at her longtime silent scourge

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Patient Reviews

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  • Rebecca Black

    Fast forward 5 years to find out incidentally I had a failing kidney. My left kidney was only functioning at 18%. During this time, I was preparing all my documents to send to Dr. Seckin to review. However, with this new information I put everything on hold and went to a urologist. After a few months, no one could figure…

  • Monique Roberts

    I'll never stop praising Dr. Seckin and his team. He literally gave me back my life.

  • Erin Brehm

    I had a wonderful experience working with Dr. Seckin and his team before, during and after my surgery. I came to Dr. Seckin having already had laparoscopic surgery for endometriosis 5 years prior, with a different surgeon. My symptoms and pain had returned, making my life truly challenging and my menstrual cycle unbearable. Dr. Seckin was quick to validate my…

  • Anita Schillhorn

    I came to Dr. Seckin after years of dealing with endometriosis and doctors who didn't fully understand the disease. He quickly ascertained what needed to be done, laid out the options along with his recommendation and gave me the time to make the right decision for me. My surgery went without a hitch and I'm healing very well. He and…

  • Nicholette Sadé

    Dr. Seckin brought me back to life! I am now 3 weeks into my recovery after my laparoscopy surgery, and I feel like a new and improved woman! Being diagnosed with Endometriosis, then 25yrs old in 2015, and discovering the severity of my case being stage 4, made me devastated. Dr. Seckin's vast knowledge of the disease, sincere empathy, and…

  • Jason Curry

    My wife had her laparoscopic excision surgery to remove endometriosis with Dr. Seckin on Jan 30, 2014. She doesn't write online reviews so I'm writing this on her behalf. I accompanied her with each office visit she had. The staff--Lucy and Kim, are very friendly, warm and professional. Dr. Seckin was excellent in every capacity. He spent a lot of…

  • Liz Filippelli

    He is an awesome doctor who saved my daughters life from debilitating endometriosis..she knew instantly upon awaking from surgery that she was better..that wad May and no complaints only praises for Dr. Wonderful Seckin!!

  • Karen N

    I was diagnosed with Endometriosis at 19. I saw several Endometriosis "Specialists" since then, had a few laproscopic surgeries to "remove" the endometriosis and continued to be in pain. I had a hysterectomy in 2012 and was told this would stop the pain once and for all. No such luck! Tired of spending days in bed with a heating pad,…

  • Lauren Rodriguez

    I researched and found Dr. Seckin after dealing with years of doctors who couldn't help me or refused to go the extra mile for their patients. I have to say I am truly blessed to have found such a compassionate and talented doctor. He is exquisite with everything he does, and both his team at the office and surgical team…

  • Kellya Vespa

    Dr. Seckin is a very skilled surgeon. There are not many doctors like him that truly understand the effects of endometriosis. I am lucky to have found him. The staff is wonderful too.

  • Meg Connolly

    Dr. Seckin truly LOVES what he does and cares about his patients from the bottom of his heart. My life has already changed in 3 weeks and I couldn’t be more grateful. Should I ever need another operation for endometriosis, Dr. Seckin will be the one to do it. I recommend him to anyone I come across with similar problems…

  • Elisandra O

    Dr. Seckin is an amazing Doctor he is very compassionate, caring and he will be honest with you. He's been my doctor for 19yrs and I am so grateful to have someone taking care of me that knows what he is doing and knows the best way to treat each and every situation. I would definitely recommend him and his…