Deep Infiltrating Endometriosis (DIE)

What is Deep Infiltrating Endometriosis (DIE)?

Deep Infiltrating Endometriosis (DIE) is a highly invasive form of endometriosis that is often characterized by rectovaginal nodules (in the space between the vagina and rectum) and disease of the uterosacral ligaments, rectum, rectovaginal septum, vagina, and bladder.

What is Deep Infiltrating Endometriosis (DIE)
This image depicts DIE scar tissue between the obliterated cul-de-sac and outer uterus. As it can be seen, the scar tissue has started to serve as a sort of "glue" between the two organs, which is the first sign of DIE beginning to lead to frozen pelvis.

What causes DIE?

When ovarian endometriomas become large enough and invade the wall of the ovaries, they begin to leak and even rupture. When this happens, the thickened blood, inflammatory enzymes and other debris that was contained in these fluid-filled enzymes, spill onto other areas within the abdominal and pelvic cavity. The contents will then adhere to these areas and begin to form the nodules and scar tissue that are often seen in cases of deep infiltrating endometriosis.

Leaking or ruptured endometriomas
Leaking or ruptured endometriomas fill other areas of the body with the “chocolate” like fluid they contain, which goes on to form nodules of DIE in areas outside of the uterus and ovaries

What are common Symptoms associated with DIE?

This significant and severe form of endometriosis is strongly associated with high levels of pelvic pain, anatomic distortion, infertility, dysuria, dysmenorrhea, dyspareunia, and gastrointestinal distress, which may include symptoms that present as irritable bowel.

What is the common surgical treatment for DIE?

Because DIE is surgically treated through the same procedure as Frozen Pelvis, more information can be seen under Frozen Pelvis (click here).

Our office is located on 872 Fifth Avenue New York, NY 10065.
You may call us at 212-988-1444 or have your case reviewed by clicking here.

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Ovarian Endometrioma (Chocolate cysts)
Ovarian Endometrioma (Chocolate cysts)

What are ovarian endometriomas (Chocolate cysts)? Ovarian endometriomas are highly common and may be present in up to 30-40% of…

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Patient Reviews

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  • Angela Aro

    I have struggled with endometriosis and adenomyosis since first starting my period at 13. I was diagnosed at 21 and what followed was a series of unsuccessful surgeries and treatments. My case was very aggressive and involved my urinary tract system and my intestines. After exhausting all of my local doctors I was lucky enough to find Dr. Seckin. We…

  • Emi O

    Seckin and Dr. Goldstein changed my life!

  • Kristin Sands

    Like so many women who have tirelessly sought a correct diagnosis and proper, thorough medical treatment for endometriosis, I found myself 26 years into this unwanted journey without clear answers or help from four previous gynecological doctors and two emergency laparoscopic surgeries. I desperately wanted to avoid the ER again; a CT scan for appendicitis also revealed a likely endometrioma…

  • Wilfredo Reyes

    Dr. Seckin literally gave my wife her life back. I am eternally grateful to him for his generous, determined spirit to see that Melanie finally live free from the prison bonds of Endometriosis.

  • Carla

    I am so grateful to Dr Seckin and Dr. Goldstein. My experience was nothing short of amazing. I was misdiagnosed with the location of my fibroids and have had a history of endometriosis. Dr. Seckin was the one who accurately diagnosed me. Dr Seckin and Dr. Goldstein really care about their patients and it shows. They listened to my concerns,…

  • Melissa Boudreau

    When I think of Dr. Seckin these are the words that come to mind. Gratitude, grateful, life-changing, a heart of gold. I feel compelled to give you a bit of background so you can understand the significance of this surgery for me. I am passionate about Endometriosis because it has affected me most of my life and I have a…

  • Jaclyn Harte

    Dr. Seckin and Dr. Goldstein radically changed my quality of life. They treat their patients with dignity & respect that I've personally never seen in the literally 25+ doctors I've seen for endometriosis. This summer, I had a surgery with Dr. Seckin & Goldstein. It was my first with them, but my 5th endo surgery. I couldn't believe the difference,…

  • Megan Rafael Moreno

    I was in pain for 2 years. I was getting no answers, and because dr Goldstein and dr seckins were willing to see and treat me I'm finally feeling almost back to normal. They were very down to earth and helpful in my time of need. Dr Goldstein was easy to talk to and caring, she took care of me…

  • Nancy Costa

    Dr. Seckin is one of the best endometriosis surgeon. Every time I go to the office, he really listens to me and is always concerned about my issues. Dr Seckin's office staff are a delight and they always work with me. I feel I can leave everything to them and they will take care of it. Thank you to the…

  • Rebecca Black

    Fast forward 5 years to find out incidentally I had a failing kidney. My left kidney was only functioning at 18%. During this time, I was preparing all my documents to send to Dr. Seckin to review. However, with this new information I put everything on hold and went to a urologist. After a few months, no one could figure…

  • Monique Roberts

    I'll never stop praising Dr. Seckin and his team. He literally gave me back my life.

  • Erin Brehm

    I had a wonderful experience working with Dr. Seckin and his team before, during and after my surgery. I came to Dr. Seckin having already had laparoscopic surgery for endometriosis 5 years prior, with a different surgeon. My symptoms and pain had returned, making my life truly challenging and my menstrual cycle unbearable. Dr. Seckin was quick to validate my…

  • Anita Schillhorn

    I came to Dr. Seckin after years of dealing with endometriosis and doctors who didn't fully understand the disease. He quickly ascertained what needed to be done, laid out the options along with his recommendation and gave me the time to make the right decision for me. My surgery went without a hitch and I'm healing very well. He and…

  • Nicholette Sadé

    Dr. Seckin brought me back to life! I am now 3 weeks into my recovery after my laparoscopy surgery, and I feel like a new and improved woman! Being diagnosed with Endometriosis, then 25yrs old in 2015, and discovering the severity of my case being stage 4, made me devastated. Dr. Seckin's vast knowledge of the disease, sincere empathy, and…